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For years, doctors recommended that older adults at a higher risk for heart attack or stroke take a low-dose aspirin once a day to lower their risk.
Lysine acetylsalicylate, also known as aspirin DL-lysine or lysine aspirin, is a more soluble form of acetylsalicylic acid (aspirin). As with aspirin itself, it is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antithrombotic and antipyretic properties. [ 1 ]
A daily aspirin dose used to be widely recommended for older adults to lower the risk of heart attacks, but doctors have since scaled back to only suggest that patients use it under specific ...
The number of adults without CVD who reported using aspirin was 14.4%, down from 20.6% in 2021. However, when stratified by age, a different picture emerges: for adults 70 and older, 38% are still ...
However, more recent trials were not able to replicate similar outcomes using low dose aspirin in low body weight (<70 kg) in specific subset of population studied i.e. elderly and diabetic population, and more evidence is required to study the effect of high dose aspirin in high body weight (≥70 kg). [107] [108] [109]
The toxic effects of salicylates have been described since at least 1877. [5] In 2004, more than 20,000 cases with 43 deaths were reported in the United States. [1] About 1% of those with an acute overdose die, while chronic overdoses may have severe outcomes. [3] Older people are at higher risks of toxicity for any given dose. [5]
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To minimize GI side effects, it is prudent to use the lowest effective dose for the shortest period of time—a practice that studies show is often not followed. Over 50% of patients who take NSAIDs have sustained some mucosal damage to their small intestine.
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