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Streptomycin is an antibiotic medication used to treat a number of bacterial infections, [3] ... albeit with minor toxicity and acquired bacterial resistance to the drug.
Streptomycin was the first effective drug in the treatment of tuberculosis, though the role of aminoglycosides such as streptomycin and amikacin has been eclipsed (because of their toxicity and inconvenient route of administration) except for multiple-drug-resistant strains.
Potential toxicity to mother and fetus during pregnancy; Enamel hypoplasia (staining of teeth; potentially permanent) Transient depression of bone growth; Inhibits the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex. But Tetracycline cannot be ...
Streptomycin, like streptothricin, possesses strong bactericidal properties, and preliminary experiments tended to indicate that the two substances are also comparable in their low toxicity to animals and in their in vivo activity. The various chemical and biological properties of streptomycin tend to point to this compound as one closely ...
Skeletal formula of tetracycline with atoms and four rings numbered and labeled.. Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. [1]
Improvements in sanitation, vaccination, and other public-health measures began significantly reducing rates of tuberculosis even before the arrival of streptomycin and other antibiotics, although the disease remained a significant threat. [42] In 1946, the development of the antibiotic streptomycin made effective treatment and cure of TB a ...
The drug proved better than streptomycin, which had nerve toxicity and to which TB could easily develop resistance. In the 1948, researchers at Britain's Medical Research Council demonstrated that combined treatment with streptomycin and PAS was superior to either drug alone, and established the principle of combination therapy for tuberculosis ...
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.