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A meta-analysis was performed to determine the association between schizophrenia and oxidative DNA damage measured by 8-hydroxy-2'-8-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). [10] Levels of 8-OHdG and 8-oxodG are widely used as measures of oxidative stress in mental illnesses including schizophrenia. [10]
Dopaminergic drugs induce the characteristic auditory hallucinations of schizophrenia if they are suddenly stopped. [dubious – discuss] Dopaminergic drug abuse such as abuse of methamphetamine may result in a short lasting psychosis or provocation of a longer psychotic episode that may include symptoms of auditory hallucinations. [21]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Cannabis is a known risk factor for developing psychosis that can progress to schizophrenia but this is the first time researchers have found brain-level changes in an at-risk population in real time.
Advanced, chronic schizophrenia can not respond even to clozapine, regarded as the most effective antipsychotic, [15] as such, a cure for highly advanced schizophrenia is likely impossible through the use of any modern antipsychotics, so the value of early intervention cannot be stressed enough.
A study done over a two-year time period shadowing patients with schizophrenia and monitoring their depression was unable to locate possible triggers such as the ones previously listed, so it is possible the nature of schizophrenia itself is the primary cause of post-schizophrenic depression. [11]
An earlier onset of schizophrenia means that patients have fewer years of biological and psychological growth before mental illness adversely affects brain development and adult coping skills.
Thought broadcasting is a type of delusional condition in which the affected person believes that others can hear their inner thoughts, despite a clear lack of evidence. The person may believe that either those nearby can perceive their thoughts or that they are being transmitted via mediums such as television, radio or the internet.
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