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The combination was first introduced as the name Trigesic, as the formula of 125 mg paracetamol, 230 mg aspirin, and 30 mg caffeine, in July 1950 by Squibb, which is now Bristol Myers Squibb, but was recalled in the following year due to several reports that the drug might cause blood dyscrasia. [5]
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Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds ...
The addition of caffeine (100–130 mg) to commonly prescribed pain relievers such as paracetamol or ibuprofen modestly improves the proportion of people who achieve pain relief. [47] Consumption of caffeine after abdominal surgery shortens the time to recovery of normal bowel function and shortens length of hospital stay. [48]
Cold therapies work for pain by decreasing the acute inflammatory response, says Bestin Kuriakose, D.O., specialist in interventional spine and pain management with New York Spine Institute ...
A Cochrane medical review of 51 trials of NSAIDs for the treatment of lower back pain found that "NSAIDs are effective for short-term symptomatic relief in patients with acute low back pain". [19] It is used for inflammatory diseases such as juvenile idiopathic arthritis and rheumatoid arthritis.
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