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It can potentially cause CNS excitement, which can lead to tremors, tachycardia (increased heart rate), and vasodilation. The vasodilation leads to a transient decrease in blood pressure, which (in dogs) increases to normal within 10 minutes. [9] There have been reports of transient hypoxemia. [25]
Fenoldopam is used as an antihypertensive agent postoperatively, and also intravenously (IV) to treat a hypertensive crisis. [4] Since fenoldopam is an intravenous agent with minimal adrenergic effects that improves renal perfusion, in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease. [5]
CCBs of the dihydropyridine group, as well as flunarizine, predominantly cause reflex tachycardia as a reaction to the low blood pressure. [4] [5] [6] Other potential symptoms include: nausea and vomiting, a decreased level of consciousness, and breathing difficulties. [2] Symptoms usually begin within 6 hours of taking the medication by mouth. [2]
Minoxidil causes a redistribution of cellular iron through its apparent capacity to bind this metal ion. By binding iron in a Fenton-reactive form, intracellular hydroxyl radical production would ensue, but hydroxyl would be immediately trapped and scavenged by the minoxidil to generate a nitroxyl radical.
The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma. [5]It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and ...
The first-dose reaction can also result in tachycardia and orthostatic hypotension, which is characterised by a feeling of extreme dizziness that gets worse with an upright posture. [1] Intravascular volume reduction, or concomitant use of other antihypertensive drugs can also lead to reflex tachycardia and orthostatic hypotension. [8]
The death of an Oregon house cat and a pet food recall are raising questions about the ongoing outbreak of bird flu and how people can protect their pets. Bird flu has been spreading for years in ...
Although relatively rare, oral antiarrhythmic medications may be proarrhythmic in some dogs; consequently, appropriate monitoring and follow-up is recommended. [2] [11] The ideal therapy for Boxer cardiomyopathy would be implantation of an implantable cardioverter-defibrillator (ICD). This has been attempted in a limited number of dogs. [12]