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An epithelial sodium channel blocker is a sodium channel blocker that is selective for the epithelial sodium channel. An example is amiloride , which is used in the treatment of hypertension . [ 1 ]
Suzetrigine (developmental code name VX-548) is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Na v 1.8-dependent pain-signaling pathways in the peripheral nervous system. [1] [2] It is being developed by Vertex Pharmaceuticals and has completed two phase 3 clinical trials. [1] [3]
Sodium channel blockers are also used as local anesthetics and anticonvulsants. [5] Sodium channel blockers have been proposed for use in the treatment of cystic fibrosis, [6] but current evidence is mixed. [7] It has been suggested that the analgesic effects of some antidepressants may be mediated in part via sodium channel blockade. [8]
Sodium channel inhibitors are used as both antiepileptics and antiarrhythmics, as they can inhibit the hyper-excitable tissues in a patient. [22] Introducing specific sodium channel blockers into a tissue allows for the preferential binding of the blocker to sodium channels, which results in an ultimate inhibition of the flow of sodium into the ...
A channel opener, also known as a channel activator, is a type of drug which facilitates ion flow through ion channels. They include the following: Potassium channel openers; Calcium channel openers; Sodium channel openers; Chloride channel openers
Potassium channel: see also Potassium channel blocker, Potassium channel opener; Sodium channel: see also Sodium channel blocker, Sodium channel opener; Chloride channel: see also Chloride channel blocker, Chloride channel opener; Transient receptor potential channel; Ligand gated ion channels. 5-HT3: see also 5-HT3 antagonist,
A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels.. Examples include toxins, such as aconitine, veratridine, batrachotoxin, robustoxin, palytoxin and ciguatoxins and insecticides (DDT and pyrethroids), which activate voltage-gated sodium channels (VGSCs), and solnatide (AP301), which activates the epithelial sodium channel (ENaC).
NKTR-171 – voltage-gated sodium channel blocker [15] PF-05089771 – selective Na v 1.7 and Na v 1.8 blocker [16] Ralfinamide (NW-1029) – non-selective voltage-gated sodium channel blocker, as well as other actions [17] Tetrodotoxin (9401-TTX; Tectin, Tetrodin, Tocudin) – non-selective voltage-gated sodium channel blocker [18]