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  2. Hyperuricemia - Wikipedia

    en.wikipedia.org/wiki/Hyperuricemia

    Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...

  3. Uric acid - Wikipedia

    en.wikipedia.org/wiki/Uric_acid

    Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]

  4. Human thermoregulation - Wikipedia

    en.wikipedia.org/wiki/Human_thermoregulation

    Simplified control circuit of human thermoregulation. [8] The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus ...

  5. Hypoxanthine-guanine phosphoribosyltransferase - Wikipedia

    en.wikipedia.org/wiki/Hypoxanthine-guanine...

    Mutations in the gene lead to hyperuricemia.At least 67 disease-causing mutations in this gene have been discovered: [5] Some men have partial (up to 20% less activity of the enzyme) HGPRT deficiency that causes high levels of uric acid in the blood, which leads to the development of gouty arthritis and the formation of uric acid stones in the urinary tract.

  6. List of temperature sensors - Wikipedia

    en.wikipedia.org/wiki/List_of_temperature_sensors

    The integrated circuit sensor may come in a variety of interfaces — analogue or digital; for digital, these could be Serial Peripheral Interface, SMBus/I 2 C or 1-Wire.. In OpenBSD, many of the I 2 C temperature sensors from the below list have been supported and are accessible through the generalised hardware sensors framework [3] since OpenBSD 3.9 (2006), [4] [5]: §6.1 which has also ...

  7. Gout - Wikipedia

    en.wikipedia.org/wiki/Gout

    An evolutionary loss of urate oxidase (uricase), which breaks down uric acid, in humans and higher primates has made this condition common. [5] The triggers for precipitation of uric acid are not well understood. While it may crystallize at normal levels, it is more likely to do so as levels increase.

  8. Protein toxicity - Wikipedia

    en.wikipedia.org/wiki/Protein_toxicity

    Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.

  9. Lesch–Nyhan syndrome - Wikipedia

    en.wikipedia.org/wiki/Lesch–Nyhan_syndrome

    The HGPRT deficiency causes a build-up of uric acid in all body fluids. The combination of increased synthesis and decreased utilization of purines leads to high levels of uric acid production. This results in both high levels of uric acid in the blood and urine, associated with severe gout and kidney problems.

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