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One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
This weight gain can be driven by physical inactivity, stress, poor sleep and poor food choices, such as eating too many ultraprocessed foods, as well as medications, experts say. Weight gain by ...
Researchers analyzed the weights of more than 183,000 adult antidepressant users six months, a year and two years after they started taking the drugs. These popular antidepressants cause the most ...
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 77 ] [ 79 ] [ 80 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 77 ]
However, most antidepressant treatments do not directly enhance DA neurotransmission, which may contribute to residual symptoms, including impaired motivation, concentration, and pleasure. [ 21 ] Preclinical and clinical research indicates that drugs inhibiting the reuptake of all three of these neurotransmitters can produce a more rapid onset ...
Monoamine reuptake inhibitors, including DRIs, have proven quite effective in managing excessive food consumption and regulating appetite in obese patients. Though such pharmacotherapy is still available, the majority of stimulant anorectics marketed for this purpose have been withdrawn or discontinued due to adverse side effects such as ...
Monoamine oxidase inhibitors (MAOIs) have a long and prosperous history as medications for major depressive disorder (MDD). But this type of antidepressant has mostly seen its day.
TCAs do not block dopamine transport directly but might facilitate dopaminergic effects indirectly by inhibiting dopamine transport into noradrenergic terminals of the cerebral cortex. [29] Because they affect so many different receptors, TCAs have adverse effects, poor tolerability, and an increased risk of toxicity. [2]