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Sodium thiosulfate, also spelled sodium thiosulphate, is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. [ 3 ] [ 4 ] [ 5 ] For cyanide poisoning, it is often used after the medication sodium nitrite and is typically only recommended for severe cases.
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na 2 S 2 O 3 ·(H 2 O) x. Typically it is available as the white or colorless pentahydrate (x = 5), which is a white solid that dissolves well in water. The compound is a reducing agent and a ligand, and these properties underpin its applications. [2]
For example, the LD50 of potassium cyanide alone is 11 mg/kg, whereas it is 21 mg/kg in the presence of sodium nitrite, giving a protective index of 1.91. The LD50 of potassium cyanide in the presence of sodium thiosulfate is 35 mg/kg, giving a protective index of 3.2.
An example is sodium thiosulfate, which the US FDA approved in 2022 to minimise the risk of ototoxicity and hearing loss in newborn, child, and adolescent cancer patients receiving cisplatin. [ 29 ] [ 30 ] [ 31 ] Other agents being investigated for their potential to reduce ototoxicity include D-methionine and L-N-acetylcysteine . [ 3 ]
The poll of 1,251 adults was conducted Dec. 5-9, 2024, using a sample drawn from NORC’s probability-based AmeriSpeak Panel, which is designed to be representative of the U.S. population.
Health officials in Europe are investigating Ozempic and the trendy drug’s possible link to an eye-rotting condition that causes blindness. On Dec. 17, the European Medicines Agency announced ...
Image credits: suburbanbeard While that 0.6% increase might not sound like a lot of money, any additional cash you can choose how you spend is valuable. Meanwhile, after-tax income, adjusted for ...