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Bone feature Definition Etymologic memory aid; apophysis: Any of various processes or protuberances on a bone. apo-+ physis, "outward from the growth part; outgrowth" diaphysis: The long, relatively straight main body of a long bone; region of primary ossification. Also known as the shaft. dia-+ physis, "between the growth parts" epiphysis
OPN expression in bone predominantly occurs by osteoblasts and osteocyctes (bone-forming cells) as well as osteoclasts (bone-resorbing cells). [29] Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN [ 30 ] Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1 , Bsp , and Opn and ...
To "make one's bones" is an American English idiom meaning to take actions to establish achievement, status, or respect. [1]It is an idiomatic equivalent of "establish[ing] one's bona fides".
The level of RANKL expression does not linearly correlate to the effect of this ligand. High protein expression of RANKL is commonly detected in the lungs, thymus and lymph nodes. Low protein expression is found in bone marrow, the stomach, peripheral blood, the spleen, the placenta, leukocytes, the heart, the thyroid, and skeletal muscle. [9]
A proverbial phrase or expression is a type of conventional saying similar to a proverb and transmitted by oral tradition. The difference is that a proverb is a fixed expression, while a proverbial phrase permits alterations to fit the grammar of the context. [1] [2] In 1768, John Ray defined a proverbial phrase as:
RANKL expression in infiltrating T cells within mammary carcinomas activate RANK-expressing neoplastic mammary epithelial cells which stimulate metastasis. The expression of RANKL in these cells and the expression of RANK in bone cells may be the biological presentation of Paget's seed and soil idea.
These cytokines act on osteoblasts to increase RANKL and decrease OPG expression resulting in excess bone resorption. [44] During resorption osteoclasts release nutrients such as growth factors and calcium from the mineralised bone matrix which cultivates a supportive environment for the proliferation and survival of tumour cells. [43]
It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found.