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Hyperammonemia, or high ammonia levels, is a metabolic disturbance characterised by an excess of ammonia in the blood. Severe hyperammonemia is a dangerous condition that may lead to brain injury and death. It may be primary or secondary. Ammonia is a substance that contains nitrogen. It is a product of the catabolism of protein.
[2] [6] It may be supported by blood ammonia levels, an electroencephalogram, or computer tomography (CT scan) of the brain. [4] [6] Hepatic encephalopathy is possibly reversible with treatment. [1] This typically involves supportive care and addressing the triggers of the event. [4] Lactulose is frequently used to decrease ammonia levels. [1]
Brain problems due to high ammonia levels; Low body temperature; Hypersensitivity reactions including multi-organ hypersensitivity syndrome; Eosinophilic pleural effusion; Bone fractures (reduced BMD with long-term use)
Lactulose is useful in treating hyperammonemia (high blood ammonia), which can lead to hepatic encephalopathy. Lactulose helps trap the ammonia (NH 3 ) in the colon and bind to it. [ 16 ] It does this by using gut flora to acidify the colon, transforming the freely diffusible ammonia into ammonium ions ( NH +
Sympathomimetic drugs can increase motivation, cognition, motor performance and alertness in persons with encephalopathy caused by brain injury, chronic infections, strokes, brain tumors. [ 10 ] When the encephalopathy is caused by untreated celiac disease or non-celiac gluten sensitivity , the gluten-free diet stops the progression of brain ...
[5] [105] The medication is also available in combination with other medications, such as hydrochlorothiazide (brand name Aldactazide, others). [ 104 ] [ failed verification ] [ 106 ] Spironolactone has poor water solubility , and for this reason, only oral and topical formulations have been developed; other routes of administration such as ...
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Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, chronic liver failure or chronic hepatic failure and end-stage liver disease, is a condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue and regenerative nodules as a result of chronic liver disease.