enow.com Web Search

  1. Ad

    related to: when was her2 discovered in america wikipedia free

Search results

  1. Results from the WOW.Com Content Network
  2. HER2 - Wikipedia

    en.wikipedia.org/wiki/HER2

    HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR.

  3. Mary L. Disis - Wikipedia

    en.wikipedia.org/wiki/Mary_L._Disis

    She was part of the investigative team who discovered that the HER2/neu molecule is a tumor-specific marker, or antigen. [ 4 ] [ 5 ] She is the founding editor in chief of JAMA Oncology .

  4. Epidermal growth factor receptor - Wikipedia

    en.wikipedia.org/wiki/Epidermal_growth_factor...

    The most common adverse effect of EGFR inhibitors, found in more than 90% of patients, is a papulopustular rash that spreads across the face and torso; the rash's presence is correlated with the drug's antitumor effect. [38] In 10% to 15% of patients the effects can be serious and require treatment. [39] [40]

  5. ErbB - Wikipedia

    en.wikipedia.org/wiki/ErbB

    The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. In humans, the family includes Her1 (EGFR, ErbB1), Her2 , Her3 , and Her4 . The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are ...

  6. Trastuzumab - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab

    The HER2 gene (also known as HER2/neu and ErbB2 gene) is amplified in 20–30% of early-stage breast cancers. [44] Trastuzumab is a monoclonal antibody targeting HER2, inducing an immune-mediated response that causes internalization and recycling of HER2. It may also upregulate cell cycle inhibitors such as p21 Waf1 and p27 Kip1. [58]

  7. Triple-negative breast cancer - Wikipedia

    en.wikipedia.org/wiki/Triple-negative_breast_cancer

    The threshold level for hormone receptor positivity was changed in 2010 and now requires more than 1% positive tumor nuclei are found in the tumor sample. [14] Newer techniques for categorising breast cancer are based on gene expression in the tumor which classifies breast cancer into: [15] [16] luminal A (HR+/HER2-) 68%; luminal B (HR+/HER2+) 10%

  8. Alpelisib - Wikipedia

    en.wikipedia.org/wiki/Alpelisib

    Alpelisib is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.

  9. Trastuzumab emtansine - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab_emtansine

    Trastuzumab binding to HER2 prevents homodimerization or heterodimerization (HER2/HER3) of the receptor, ultimately inhibiting the activation of MAPK and PI3K/AKT cellular signalling pathways. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the cytotoxic agent DM1 ...

  1. Ad

    related to: when was her2 discovered in america wikipedia free