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Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
Treatment-resistant depression is when a person’s depression doesn’t respond to at least two different types of antidepressants. About 30% of people with major depressive disorder do not ...
For treatment-resistant depression, adding on the atypical antipsychotic brexpiprazole for short-term or acute management may be considered. [209] Brexpiprazole may be effective for some people, however, the evidence as of 2023 supporting its use is weak and this medication has potential adverse effects including weight gain and akathisia. [209]
Research shows that approximately one-third of people with depression have treatment-resistant depression (TRD). With TRD, depression doesn’t always improve through standard treatments, like ...
In the immediate aftermath of a high-profile suicide of a beloved celebrity like Naomi Judd, calls to suicide-prevention hotlines tend to increase.
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