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Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
The main biological role of progestogens in the body is in the female reproductive system, and the male reproductive system, [19] with involvement in regulation of the menstrual cycle, maintenance of pregnancy, and preparation of the mammary glands for lactation and breastfeeding following parturition in women; in men progesterone affects ...
[125] [126] [44] In addition, progesterone can be hydroxylated in the liver by other cytochrome P450 enzymes which are not steroid-specific. [127] 6β-Hydroxylation, which is catalyzed mainly by CYP3A4, is the major transformation, and is responsible for approximately 70% of cytochrome P450-mediated progesterone metabolism. [127]
At high doses, progestogens can cause low sex hormone levels and associated side effects like sexual dysfunction and an increased risk of bone fractures. [3] Progestogens are agonists of the progesterone receptors (PRs) and produce progestogenic, or progestational, effects. [1]
"In some women, taking outside progesterone, or what we call 'exogenous progesterone,' either in the form of birth control or for other reasons, can sometimes cause your immune system to become ...
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...
Through their ability to cause amenorrhea, progestogen-only pills can help reduce the symptoms associated with this condition. Levonorgestrel-IUDs may be more effective than progestogen-only pills and reducing associated bleeding (maintaining healthy hemoglobin levels), uterine volume, and pain, although both methods have shown a beneficial ...
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