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p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
P53 function can also be responsible for a limited life span where mutations of the p53 gene causes expression of dominant-negative forms producing long lived animals. For example in an experiment using C. elegans , the increased life span of p53 mutants was found to depend on increased autophagy. [ 19 ]
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5] [6] In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. [5] [6] The expression of PUMA is regulated by the tumor suppressor p53.
The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]
[14] [15] About two months later, scientists reported that they created the first complete neuron-level-resolution 3D map of a monkey brain which they scanned via a new method within 100 hours. They made only a fraction of the 3D map publicly available as the entire map takes more than 1 petabyte of storage space even when compressed.
A photo of two people holding hands While speaking to The Times , Parry-Wingfield and Denman recalled being put in touch by a mutual friend, just before the latter had her operation.
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Scrolling on social media is also a way to "disassociate" and give the brain a rest after a long day, Bobinet said. This is an "avoidance behavior," which the habenula controls.