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Heterozygosity values of 51 worldwide human populations. [10] Sub-Saharan Africans have the highest values in the world. In population genetics, the concept of heterozygosity is commonly extended to refer to the population as a whole, i.e., the fraction of individuals in a population that are heterozygous for a particular locus. It can also ...
The remaining copy of the tumor suppressor gene can be inactivated by a point mutation or via other mechanisms, resulting in a loss of heterozygosity event, and leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell).
One of the most important measures of genomic health is the ratio of expected heterozygosity to measured heterozygosity. Generally, an individual or species with more heterozygous alleles have a higher chance of survival. This is known as heterosis. [4] Low levels of heterozygosity is a sign of possible concern for a species or organism.
RecLOH is a term in genetics that is an abbreviation for "Recombinant Loss of Heterozygosity".. This is a type of mutation which occurs with DNA by recombination.From a pair of equivalent ("homologous"), but slightly different (heterozygous) genes, a pair of identical genes results.
Heterozygosity is the fraction of individuals in a population that are heterozygous for a particular locus. Alleles per locus is also used to demonstrate variability. Nucleotide diversity is the extent of nucleotide polymorphisms within a population, and is commonly measured through molecular markers such as micro- and minisatellite sequences ...
In medical genetics, compound heterozygosity is the condition of having two or more heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state; that is, an organism is a compound heterozygote when it has two recessive alleles for the same gene, but with those two alleles being different from each other (for example, both alleles might be ...
In population genetics, the Wahlund effect is a reduction of heterozygosity (that is when an organism has two different alleles at a locus) in a population caused by subpopulation structure. Namely, if two or more subpopulations are in a Hardy–Weinberg equilibrium but have different allele frequencies , the overall heterozygosity is reduced ...
The measures F IS, F ST, and F IT are related to the amounts of heterozygosity at various levels of population structure. Together, they are called F-statistics, and are derived from F, the inbreeding coefficient. In a simple two-allele system with inbreeding, the genotypic frequencies are: