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Although it is not commercialised as antibiotic due to its adverse effects, its modified compound (ester derivative) is an approved immunosuppressant drug in kidney, heart, and liver transplantations, and is marketed under the brands Cellcept (mycophenolate mofetil by Roche) and Myfortic (mycophenolate sodium by Novartis). [46]
Drug-induced lupus erythematosus is an autoimmune disorder caused by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of systemic lupus erythematosus (SLE).
Neurological disorders contribute to a significant percentage of morbidity and mortality in people with lupus. [47] As a result, the neural side of lupus is being studied in hopes of reducing morbidity and mortality rates. [39] One aspect of this disease is severe damage to the epithelial cells of the blood–brain barrier. In certain regions ...
Kezar was testing the drug in patients with active lupus nephritis, which causes inflammation and damage in the kidneys due to a form of immune-related condition called lupus.
Patients with juvenile-onset lupus are more vulnerable to mucocutaneous manifestations of the disease (alopecia, skin rash, and ulceration of the mucous membranes) than any other age group, and they are also more susceptible to evaluation of pulmonary artery pressure. [7] However, patients with late-onset lupus have a much higher mortality rate.
Asian patients appear to be affected by lupus erythematosus panniculitis at a slightly younger age group, with a mean age of 31. [ 18 ] [ 19 ] Cases involving children are uncommon. [ 20 ] [ 21 ] Rarely, neonatal lupus has been linked to lupus erythematosus panniculitis.
Most patients with a lupus anticoagulant do not actually have lupus erythematosus, and only a small proportion will proceed to develop this disease (which causes joint pains, skin problems and kidney failure, amongst other complications). People with lupus erythematosus are more likely to develop a lupus anticoagulant than the general population.
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases. [3] [4] It is a type of glomerulonephritis in which the glomeruli become inflamed.