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A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression of osteoarthritis. [1] Since the main hallmark of osteoarthritis is cartilage loss, a typical DMOAD would prevent the loss of cartilage and potentially regenerate it.
[citation needed] More recently, the term has been used to indicate a drug that reduces the rate of damage to bone and cartilage. [ citation needed ] DMARDs can be further subdivided into traditional small molecular mass drugs synthesised chemically and newer "biological" agents produced through genetic engineering.
Methotrexate is commonly associated with dose-related toxic effects involving the bone marrow and gastrointestinal tract. [12] Folic acid may be given weekly to help diminish the frequency of side-effects. [12] Methotrexate is also associated with acute and chronic liver damage. Other adverse effects include: [12] Life-threatening Interstitial ...
Pharmaceutical agents that will alter the natural history of disease progression by arresting joint structural change and ameliorating symptoms are termed as disease modifying therapy. [63] Therapies under investigation include the following: Strontium ranelate – may decrease degeneration in osteoarthritis and improve outcomes [202] [203]
1.09 Alkylating agents: Altretamine: PO Alkylates DNA. Recurrent or advanced ovarian cancer Myelosuppression, peripheral neuropathy, seizures and hepatotoxicity (rare). Bendamustine: IV: Alkylates DNA. Chronic lymphocytic leukaemia, mantle cell lymphoma and non-Hodgkin's lymphoma. Myelosuppression, hypokalaemia and tachycardia. Busulfan: IV, PO ...
1 Promoting Healthy Choices: Information vs. Convenience Jessica Wisdom, Julie S. Downs and George Loewenstein Contact Information: We thank the USDA Economic Research Service and the Center for Behavioral Decision
Biological response modifiers (BRMs) are substances that modify immune responses.They can be endogenous (produced naturally within the body) or exogenous (as pharmaceutical drugs), and they can either enhance an immune response or suppress it.
"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." Sugar-sweetened beverages may increase your risk for heart disease and type 2 diabetes, new research ...