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In this diagram of a duplicated chromosome, (2) identifies the centromere—the region that joins the two sister chromatids, or each half of the chromosome. In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere links a pair of sister chromatids together during cell ...
The centrosome is copied only once per cell cycle, so that each daughter cell inherits one centrosome, containing two structures called centrioles. The centrosome replicates during the S phase of the cell cycle. During the prophase in the process of cell division called mitosis, the centrosomes migrate to opposite poles of the cell. The mitotic ...
Kinetochores start, control, and supervise the striking movements of chromosomes during cell division. During mitosis, which occurs after the amount of DNA is doubled in each chromosome (while maintaining the same number of chromosomes) in S phase, two sister chromatids are held together by a centromere. Each chromatid has its own kinetochore ...
During cell division, the identical copies (called a "sister chromatid pair") are joined at the region called the centromere (2). Once the paired sister chromatids have separated from one another (in the anaphase of mitosis ) each is known as a daughter chromosome.
Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. [5] CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome [ 6 ] in most eukaryotes including humans.
Early data suggesting that S phase is crucial to cohesion was based on the fact that after S phase, sister chromatids are always found in the bound state. Tying establishment to DNA replication allows the cell to institute cohesion as soon as the sister chromatids are formed. This solves the problem of how the cell might properly identify and ...
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Bottom: Two tomato SCs with the chromatin removed, allowing kinetochores ("ball-like" structures) at centromeres to be revealed. The synaptonemal complex ( SC ) is a protein structure that forms between homologous chromosomes (two pairs of sister chromatids ) during meiosis and is thought to mediate synapsis and recombination during prophase I ...