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Congenital rubella syndrome (CRS) occurs when a human fetus is infected with the rubella virus (German measles) via maternal-fetal transmission and develops birth defects. [1] The most common congenital defects affect the ophthalmologic, cardiac, auditory, and neurologic systems.
During the epidemic in the US between 1962 and 1965, rubella virus infections during pregnancy were estimated to have caused 30,000 stillbirths and 20,000 children to be born impaired or disabled as a result of CRS. [40] [41] Universal immunisation producing a high level of herd immunity is important in the control of epidemics of rubella. [42]
Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy. Rubella virus, scientific name Rubivirus rubellae, is a member of the genus Rubivirus and belongs to the ...
Maternal infection with rubella virus during pregnancy can lead to congenital rubella syndrome. The risk of congenital infection is highest during the first trimester (< 12 weeks). Risk of congenital rubella is increased among immigrant women from countries without adequate vaccination programs.
Rubella vaccine is a vaccine used to prevent rubella. [1] Effectiveness begins about two weeks after a single dose and around 95% of people become immune. Countries with high rates of immunization no longer see cases of rubella or congenital rubella syndrome.
A variant of the rustrela virus-- related to the wider-known rubella virus which causes a skin rash in humans -- called RusV was discovered in a female mountain lion in Douglas County, Colorado ...
With new information out about the effects of the Rubella virus on a fetus, some expectant women and physicians wanted the termination of the pregnancy to be an option. Abortion was illegal in the United States at the height of this epidemic, however, physicians were allowed to perform therapeutic abortions if the believed the mother would be ...
Rubella, or German measles, is an infection caused by the rubella virus. In childhood, it usually causes a mild disease but infection in pregnancy can result in fetal infection, or congenital rubella syndrome, which causes neonatal deaths, deafness, blindness and intellectual disabilities. The first rubella vaccine was licensed for use in 1969 ...