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  2. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    Insulin is synthesized and secreted in the beta cells of the islets of Langerhans. Once insulin is synthesized, the beta cells are ready to release it in two different phases. As for the first phase, insulin release is triggered rapidly when the blood glucose level is increased.

  3. Insulin regulatory sequence - Wikipedia

    en.wikipedia.org/wiki/Insulin_regulatory_sequence

    Transcription of insulin is regulated by the binding of various transcription factors to the ~400 base pairs before the insulin transcription start site, called the "insulin regulatory sequence". [1] This sequence is made up of several distinct regions with different biochemical properties, each of which serve as binding sites for distinct ...

  4. Blood sugar regulation - Wikipedia

    en.wikipedia.org/wiki/Blood_sugar_regulation

    Diabetes mellitus type 1 is caused by insufficient or non-existent production of insulin, while type 2 is primarily due to a decreased response to insulin in the tissues of the body (insulin resistance). Both types of diabetes, if untreated, result in too much glucose remaining in the blood (hyperglycemia) and many of the same complications.

  5. Insulin (medication) - Wikipedia

    en.wikipedia.org/wiki/Insulin_(medication)

    Early initiation of insulin therapy for the long-term management of conditions such as type 2 diabetes would suggest that the use of insulin has unique benefits, however, with insulin therapy, there is a need to gradually raise the dose and the complexity of the regimen, as well as the likelihood of developing severe hypoglycemia which is why ...

  6. What Is Diabetes: Risk Factors & Treatment - AOL

    www.aol.com/diabetes-risk-factors-treatment...

    Diabetes is a condition that causes blood sugar levels to become higher than normal. This is due to problems with how the body makes or uses insulin, the hormone that manages blood sugar (glucose ...

  7. Insulin receptor - Wikipedia

    en.wikipedia.org/wiki/Insulin_receptor

    The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.

  8. Diabetes: Everything You Need to Know, from Symptoms to ... - AOL

    www.aol.com/diabetes-everything-know-symptoms...

    Diabetes is a condition where the body doesn’t make enough insulin or doesn’t use insulin well. ... Metformin is one of the most common first-line medications for type 2 diabetes. Side effects ...

  9. Glucokinase - Wikipedia

    en.wikipedia.org/wiki/Glucokinase

    Glucokinase in beta cells serves as a glucose sensor, amplifying insulin secretion as blood glucose rises. In the pancreatic beta-cell, glucokinase is a key regulator enzyme. Glucokinase is very important in the regulation of insulin secretion and has been known as the pancreatic beta-cell sensor.