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A dry-powder inhaler (DPI) is a device that delivers medication to the lungs in the form of a dry powder. DPIs are commonly used to treat respiratory diseases such as asthma, bronchitis, emphysema and COPD although DPIs (such as inhalable insulin) have also been used in the treatment of diabetes mellitus. [1]
Inhalable insulin is a powdered form of insulin, delivered with an inhaler into the lungs where it is absorbed. [1] In general, inhaled insulins have been more rapidly absorbed than subcutaneous injected insulin, with faster peak concentration in serum and more rapid metabolism.
A wide range of volatile solvents intended for household or industrial use are inhaled as recreational drugs. This includes petroleum products (gasoline and kerosene), toluene (used in paint thinner, permanent markers, contact cement and model glue), and acetone (used in nail polish remover). These solvents vaporize at room temperature.
Toluene is widely used in the paint, dye, rubber, chemical, glue, printing, and pharmaceutical industries as a solvent. [38] Nail polish, paintbrush cleaners, and stain removers may contain toluene. Manufacturing of explosives (TNT) uses it as well. Toluene is also found in cigarette smoke and car exhaust.
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Insulin is used to treat a number of diseases including diabetes and its acute complications such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. It is also used along with glucose to treat high blood potassium levels. Use during pregnancy is relatively safe for the baby. [6]
Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with sulfonylurea, metformin, or insulin. [1] The effects of pioglitazone have been compared in a Cochrane systematic review to that of other blood sugar lowering-medicine, including metformin, acarbose, and repaglinide, as well as with appropriate diet and exercise, not showing any benefit in ...
2,4-Diaminotoluene, precursor to toluene diisocyanate and azo dye. 2,6-Diaminotoluene, a common impurity in 2,4-diaminotoluene 2,5-Diaminotoluene , precursor to hair dyes.
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