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  2. Insulin Resistance: From Symptoms to Treatment - AOL

    www.aol.com/insulin-resistance-symptoms...

    Insulin resistance, or low insulin sensitivity, happens when cells throughout the body don’t respond properly to the hormone insulin, especially cells in muscles, fat and the liver. Insulin is a ...

  3. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    Insulin is synthesized and secreted in the beta cells of the islets of Langerhans. Once insulin is synthesized, the beta cells are ready to release it in two different phases. As for the first phase, insulin release is triggered rapidly when the blood glucose level is increased.

  4. Insulin resistance - Wikipedia

    en.wikipedia.org/wiki/Insulin_resistance

    The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Professor Wilhelm Falta and published in Vienna in 1931, [70] and confirmed as contributory by Sir Harold Percival Himsworth of the University College Hospital Medical Centre in London in 1936; [71] however, type 2 diabetes does not ...

  5. Randle cycle - Wikipedia

    en.wikipedia.org/wiki/Randle_cycle

    The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the cross inhibition of glucose and fatty acids for substrates. [1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance.

  6. Insulin receptor - Wikipedia

    en.wikipedia.org/wiki/Insulin_receptor

    The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.

  7. The One Thing You Should Never, Ever Do if You Have Insulin ...

    www.aol.com/one-thing-never-ever-insulin...

    An estimated 40% of adults in the U.S. between the ages of 18 and 44 have insulin resistance, which is when the body doesn’t respond the way it should to insulin, a hormone the pancreas makes ...

  8. Beta cell - Wikipedia

    en.wikipedia.org/wiki/Beta_cell

    Beta cells are the only site of insulin synthesis in mammals. [7] As glucose stimulates insulin secretion, it simultaneously increases proinsulin biosynthesis through translational control and enhanced gene transcription. [4] [8] The insulin gene is first transcribed into mRNA and translated into preproinsulin. [4]

  9. Diabetes: Everything You Need to Know, from Symptoms to ... - AOL

    www.aol.com/diabetes-everything-know-symptoms...

    Having overweight or obesity can lead to insulin resistance and raises ... Metformin is one of the most common first-line medications for type 2 diabetes. Side effects of diabetes medications can ...