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Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Diagnosis of schizophrenia from non-psychotic disorders Sensitivity 61.8 (51.7, 71.0) Specificity 94.1 (88.0, 97.2) 55% (19% to 89%) With a prevalence of 55%, 55 out of every 100 people with non-psychotic disorders will have schizophrenia. Of these, 21 will not be identified as having schizophrenia by use of FRS (38% of 55).
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Schizophrenia is a mental disorder characterized by significant alterations in perception, thoughts, mood, and behavior. [34] Symptoms are described in terms of positive, negative, and cognitive symptoms. [3] [35] The positive symptoms of schizophrenia are the same for any psychosis and are sometimes referred to as psychotic symptoms. These may ...
Medication may improve the positive symptoms of schizophrenia, and social and vocational functioning. [6] However, antipsychotics fail to significantly improve the negative symptoms and cognitive dysfunction. [7] [8] There is evidence of clozapine, amisulpride, olanzapine, and risperidone being the most effective
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
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Saphris – atypical antipsychotic used to treat schizophrenia and bipolar disorder; Serax – anti-anxiety medication of the benzodiazepine class, often used to help during detoxification from alcohol or other addictive substances; Serentil (mesoridazine) – an antipsychotic drug used in the treatment of schizophrenia [1]
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