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A subunit vaccine is a vaccine that contains purified parts of the pathogen that are antigenic, or necessary to elicit a protective immune response. [1] [2] Subunit vaccine can be made from dissembled viral particles in cell culture or recombinant DNA expression, [3] in which case it is a recombinant subunit vaccine.
OPV is an attenuated vaccine, produced by the passage of the virus through nonhuman cells at a subphysiological temperature, which produces spontaneous mutations in the viral genome. [53] Oral polio vaccines were developed by several groups, one of which was led by Albert Sabin.
The Global Polio Eradication Initiative is an initiative created in 1988, just after the World Health Assembly resolved to eradicate the disease poliomyelitis. [1] Led by the World Health Organization , it is the largest international public health initiative in history.
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
A child receives oral polio vaccine during a 2002 campaign to immunize children in India. Poliovirus. Polio eradication, the goal of permanent global cessation of circulation of the poliovirus and hence elimination of the poliomyelitis (polio) it causes, is the aim of a multinational public health effort begun in 1988, led by the World Health Organization (WHO), the United Nations Children's ...
March of Dimes is a United States nonprofit organization that works to improve the health of mothers and babies. [1] The organization was founded by US President Franklin D. Roosevelt in 1938, as the National Foundation for Infantile Paralysis, to combat polio.
Polio eradication, the goal of permanent global cessation of circulation of the poliovirus and hence elimination of the poliomyelitis (polio) it causes, is the aim of a multinational public health effort begun in 1988, led by the World Health Organization (WHO), the United Nations Children's Fund (UNICEF) and the Rotary Foundation. [55]
Poliovirus causes Polio, or Poliomyelitis, which is a disabling and life-threatening disease that causes paresthesia, meningitis and permanent paralysis. [16] Symptoms can include sore throat, fever, tiredness, nausea, headache and stomach pain although 72% of those that get infected will not display visible symptoms. [ 16 ]