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Dimenhydrinate is an over-the-counter (OTC) first-generation antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. [2] Dimenhydrinate can also be used for Insomnia, but this is an off label use. [5]
However, both scopolamine and antihistamines can cause drowsiness and sedation, Dr. Strachan warns — meaning that it's best to avoid these options if you're driving or traveling alone for longer ...
Travelers can also turn to medications like Dramamine or Benadryl, which Adamian recommended taking 30 to 60 minutes in advance (though she noted they cause drowsiness). Those can also help ...
Dimenhydrinate; Alkylamines: The isomerism is a significant factor in the activity of the agents in this group. E-triprolidine, for example, is 1000-fold more potent than Z-triprolidine. This difference relates to the positioning and fit of the molecules in the histamine H 1-receptor binding site. [15]
The evidence does not report how antihistamines affect women differently than men. [1] Different studies have reported on antihistamine use in children, with various studies finding evidence that certain antihistamines could be used by children 2 years of age, and other drugs being safer for younger or older children.
Some common side effects such as drowsiness, dry mouth, and tiredness may occur. Meclizine has been shown to have fewer dry mouth side effects than the traditional treatment for motion sickness, transdermal scopolamine. [16] A very serious allergic reaction to this drug is unlikely, but immediate medical attention should be sought if it occurs.
Dimenhydrinate (Gravol, Dramamine) Doxylamine (Bonjesta, Unisom) Mirtazapine (Remeron) is an antidepressant that also has antiemetic effects. [5] [6] It is a potent histamine H1 receptor antagonist, K i =1.6 nM, [7] and also exhibits notable 5-HT 3 antagonism. [6] Meclizine (Bonine, Antivert)
This could also cause a “marked lack of enthusiasm for daily tasks,” Porter says, adding that these symptoms “go beyond” normal fatigue. What is the connection between sleep and preventing ...