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Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which fluconazole is not. The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits the fungal-mediated synthesis of ergosterol .
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. [ 7 ] [ 8 ] It was approved for medical use in the European Union in October 2005, [ 6 ] and in the United States in September 2006.
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. [5] This includes aspergillosis , candidiasis , coccidioidomycosis , histoplasmosis , penicilliosis , and infections by Scedosporium or Fusarium . [ 5 ]
The hyphae of Aspergillus species range in diameter from 2.5 to 4.5 μm. They have septate hyphae, [28] but these are not always apparent, and in such cases they may be mistaken for Zygomycota. [27] Aspergillus hyphae tend to have dichotomous branching that is progressive and primarily at acute angles of around 45°. [27]
Second-generation triazoles, including voriconazole, posaconazole and ravuconazole, are more potent and more active against resistant pathogens. [ 2 ] For wood preservation , other azoles such as propiconazole , tebuconazole and cyproconazole , are used as antifungal agents in several wood products or structures, with or without the addition of ...
Newer triazole drugs—such as posaconazole or voriconazole—have not yet been studied in-depth through clinical trials in this context. [ 30 ] [ 31 ] While the benefits of using corticosteroids in the short term are notable, and improve quality of life scores, there are cases of ABPA converting to invasive aspergillosis while undergoing ...
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Chronic pulmonary aspergillosis is a long-term fungal infection caused by members of the genus Aspergillus—most commonly Aspergillus fumigatus. [8] The term describes several disease presentations with considerable overlap, ranging from an aspergilloma [12] —a clump of Aspergillus mold in the lungs—through to a subacute, invasive form known as chronic necrotizing pulmonary aspergillosis ...
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