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Isavuconazonium comprises an N-(3-acetoxypropyl)-N-methylamino-carboxymethyl group linked through an ester moiety to the triazole nitrogen in isavuconazole. [ 16 ] [ 17 ] [ 18 ] In the aquatic media of the body, the isavuconazole molecule is transformed into monohydrate.
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. [1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. [2]
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
English: Skeletal formula of isavuconazonium sulfate (brand name Cresemba, previously known as BAL8557)—a prodrug of isavuconazole, an antifungal drug. Created with ChemDoodle 7.0.2 and Adobe Illustrator CC .
Tavaborole, sold under the brand name Kerydin, is a topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed with a complete clearance rate of 6-7% and partial clearance rate of 23-24% in individuals whose “infection border does not reach the cuticle at the base of the large toenail.” [1] Tavaborole was approved by the US FDA in July ...
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Fosravuconazole (trade name Nailin) is a triazole antifungal agent. [1] [2] In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. [3]It is a prodrug that is converted into ravuconazole.
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