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Astressin-B is a nonselective corticotropin releasing hormone antagonist that reduces the synthesis of adrenocorticotropic hormone and cortisol. [1] It reduces the synthesis of adrenocorticotropic hormone and improves the sexual drive of rats under stressing conditions. [2] Astressin-B is able to delay the emptying of solid food in mice. [3]
Antagonists acting at CRF-2 have also been developed, such as the peptide Astressin-B, [8] but so far no highly selective agents for CRF-2 subtypes are available. There is an increased interest in research on the combinational treatment of CRF-1 and CRF-2 antagonists, along with concurrent SSRI treatment, [5] for the treatment of anxiety disorders.
6752 20606 Ensembl ENSG00000180616 ENSMUSG00000047904 UniProt P30874 P30875 RefSeq (mRNA) NM_001050 NM_001042606 NM_009217 RefSeq (protein) NP_001041 NP_001036071 NP_033243 Location (UCSC) Chr 17: 73.17 – 73.18 Mb Chr 11: 113.51 – 113.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. The SSTR2 ...
In other words, evidence from a few studies suggests that GLP-1-agonist-induced weight loss may lead to expected levels of muscle loss while improving muscle quality, but further research is needed.
This research comes at a time when an increasing number of Americans are reporting symptoms of depression. A 2023 Gallup survey found that self-reported rates of depression had increased by 10% ...
AllTrials (sometimes called All Trials or AllTrials.net) is a project advocating that clinical research adopt the principles of open research.The project summarizes itself as "All trials registered, all results reported": that is, all clinical trials should be listed in a clinical trials registry, and their results should always be shared as open data.
New research from Vanguard suggests people changing jobs put less into their 401(k)s, often without realizing it, and can lose out on as much as $300,000 throughout their careers.
Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. [1] When expressed specifically, a clinical trial phase is capitalized both in name and Roman numeral, such as "Phase I" clinical trial. [1]
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