Search results
Results from the WOW.Com Content Network
The "early", "middle" (DNA replication), and "late" genes (virus structure), roughly represent the time course of gene expression. [74] Bacteriophage genomes can be highly mosaic, i.e. the genome of many phage species appear to be composed of numerous individual modules. These modules may be found in other phage species in different arrangements.
The structures of the phage capsid and of some other phage proteins are available from the Protein Data Bank. [6] The single-stranded Ff phage DNA runs down the central core of the phage, and is protected by a cylindrical protein coat built from thousands of identical α-helical major coat protein subunits coded by phage gene 8.
Assembled major coat protein, exploded view. The virion is a flexible filament (worm-like chain) about 6 nm in diameter and 900 nm long.Several thousand copies of a small (50 amino-acid residues) elongated alpha-helical major coat protein subunit (the product of gene 8, or p8) in an overlapping shingle-like array form a hollow cylinder enclosing the circular single-stranded DNA genome.
The phage first adheres to the cell surface with its tail parallel to or leaning at an angle to the cell surface in the pre-infection stage. The tail then firmly stands on the cell surface and extends its fibers horizontally, rendering the phage infection-competent, after which viral DNA is released into the cell through an extensible tube. [21]
The phage is covered by a protective protein coat. The T2 phage can quickly turn an E. coli cell into a T2-producing factory that releases phages when the cell ruptures. Experiments conducted in 1952 by Alfred Hershey and Martha Chase demonstrated how the DNA of viruses is injected into the bacterial cells, while most of the viral proteins ...
Structure of phage ΦX174 capsid Schematic drawing of a Sinsheimervirus (aka Phix174microvirus) virion. The phi X 174 (or ΦX174) bacteriophage is a single-stranded DNA virus that infects Escherichia coli.
Total phage representation in the virome is higher in individuals with Cardiovascular disease than healthy controls, totaling 63% and 18% respectively. [6] Lastly, researchers studying Colorectal cancer have observed increased richness in a variety of phage genera, with the most notable differences seen in Inovirus and Tunalikevirus.
M13 is one of the Ff phages (fd and f1 are others), a member of the family filamentous bacteriophage ().Ff phages are composed of circular single-stranded DNA (), which in the case of the m13 phage is 6407 nucleotides long and is encapsulated in approximately 2700 copies of the major coat protein p8, and capped with about 5 copies each of four different minor coat proteins (p3 and p6 at one ...