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Gestational pemphigoid (GP) is a rare autoimmune variant of the skin disease bullous pemphigoid, and first appears in pregnancy. [2] It presents with tense blisters, small bumps, hives and intense itching, usually starting around the navel before spreading to limbs in mid-pregnancy or shortly after delivery. [1]
(Others are: toxoplasmosis, rubella and herpes simplex.) Congenital HCMV infection occurs when the mother has a primary infection during pregnancy. [33] [34] [35] Up to 5 of every 1,000 live births are infected. Five percent develop multiple handicaps, and develop cytomegalic inclusion disease with nonspecific signs that resemble rubella ...
Nine herpesvirus types are known to primarily infect humans, [7] at least five of which are extremely widespread among most human populations, and which cause common diseases: herpes simplex 1 and 2 (HSV-1 and HSV-2, also known as HHV-1 and HHV-2; both of which can cause orolabial and genital herpes), varicella zoster (VZV or HHV-3; the cause ...
Genital herpes is a herpes infection of the genitals caused by the herpes simplex virus (HSV). [1] Most people either have no or mild symptoms and thus do not know they are infected. [ 1 ] When symptoms do occur, they typically include small blisters that break open to form painful ulcers . [ 1 ]
Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. [5] Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes , though other forms also exist.
Herpes virus DNA contains a gene for a protein called ICP4, which is an important transactivator of genes associated with lytic infection in HSV-1. [47] Elements surrounding the gene for ICP4 bind a protein known as the human neuronal protein neuronal restrictive silencing factor (NRSF) or human repressor element silencing transcription factor ...
Herpes gestationis: DR3 DR4 Epidermolysis bullosa acquisita: DR2 Subacute cutaneous lupus erythematosus: DR3 Dermatomyositis: DQA1 DR3 B8 DRw52 Alopecia areata: DR5 Sjögren's syndrome: DR3 DQ2 Herpes simplex virus-related erythema multiforme: B12 Chronic idiopathic urticaria: DR4 DQ8 Actinic prurigo: DR4 subtype DRB1*0407 Systemic lupus ...
Sometimes, people may require a 3- or 4-mm punch biopsy to exclude herpes gestationis, which is a variant of bullous pemphigoid occurring during or immediately after pregnancy. Usually the biopsy has features that are consistent with PUPPP but there are no pathognomonic symptoms of the particular disorder.