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About 60% of the metronidazole is metabolized by oxidation to the main metabolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The metabolites show antibiotic and antiprotozoal activity in vitro. [61] Metronidazole and its metabolites are mainly excreted via the kidneys (77%) and to a lesser extent via the ...
Metronidazole is less effective, but is available in a gel and can be applied twice daily. For pediatric patients, metronidazole can be used as an alternative to tetracycline. Metronidazole comes in various concentrations ranging from 0.75% to 2%. Higher concentrated metronidazole did not equate to shorter time to cure times. [27]
Although rosacea was first described by Guy de Chauliac in the 14th century and included Chaucer's The Canterbury Tales, [2] when the National Rosacea Society was founded in 1992 rosacea was still considered a rare disease, and its first approved treatment, topical metronidazole, received orphan drug designation by the U.S. Food and Drug Administration in the belief that fewer than 200,000 ...
Consistency and viscosity affect the adhesion and retention property of the gel, and are important in ensuring the gel is retained at the site of application and effective delivery of the drug. [ 3 ] The ingredients in topical gel formulation can be broadly categorized into four types: gelator, solvent, drug, and excipients.
Topical 0.75% and 1% Metronidazole [10] [11] Topical 4% nicotinamide [3] Topical sulfacetamide [11] Tea tree oil [12] Cannabidiol shampoo [24] Frequent washing to avoid the build-up of scale, especially on the scalp, but while avoiding overly drying the skin [12] [11] [20] Avoiding damaging skin with harsh grooming or chemical irritants [20]
They’re also known as jelly beads, hydro orbs, crystal soil and gel beads, HealthyChildren.org said. An estimated 7,800 children went to the emergency room after ingesting water beads between ...
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