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Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction. albendazole + NADPH + H + + O 2 albendazole S-oxide + NADP + + H 2 O. The four substrates of this enzyme are albendazole, NADPH, H +, and O 2, whereas its three products are albendazole S-oxide, NADP +, and H 2 O.
In humans, mebendazole (200–400 mg three times a day for three days) or albendazole (400 mg twice a day for 8–14 days) is given to treat trichinosis. [30] These drugs prevent newly hatched larvae from developing, but should not be given to pregnant women or children under two years of age. [10]
Mass deworming of children can be carried out by administering mebendazole and albendazole which are two types of anthelmintic drug. [5] The cost of providing one tablet every six to twelve months per child (typical doses) is relatively low. [6] Soil-transmitted helminthiasis is the most prevalent neglected tropical disease. [7]
Other drugs that can be effective are albendazole and thiabendazole (25 mg/kg twice daily for 5 days—400 mg maximum (generally)). [11] All patients who are at risk of disseminated strongyloidiasis should be treated. The optimal duration of treatment for patients with disseminated infections is not clear. [10]
ATC code P02 Anthelmintics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
What is the dose of albendazole to be taken for a patient having Hook Worm ++? −The FDA only allows this drug to be indicated for the treatment of Pork Tapeworm, and Dog Tapeworm. Doctors may use it to treat other infestations as literature (JAMA) is presented Sammorxman 15:51, 13 October 2006 (UTC) Sam M. Pharmacist [ reply ]
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