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The de novo protein synthesis theory of memory formation is a hypothesis about the formation of the physical correlates of memory in the brain. It is widely accepted that the physiological correlates for memories are stored at the synapse between various neurons .
Protein synthesis plays an important role in the formation of new memories. Studies have shown that protein synthesis inhibitors administered after learning, weaken memory, suggesting that protein synthesis is required for memory consolidation. Additionally, reports have suggested that the effects of protein synthesis inhibitors also inhibit ...
Studies with protein synthesis inhibitors showed that blocking protein synthesis did not block memory retention. [19] Stable LTP were found in slice preparation of the hippocampus under a state of global protein synthesis inhibition. [20] Those studies show that LTP stabilization can happen independently from protein synthesis.
Specifically, it is unclear whether protein synthesis takes place in the postsynaptic cell body or in its dendrites. [39] Despite having observed ribosomes (the major components of the protein synthesis machinery) in dendrites as early as the 1960s, prevailing wisdom was that the cell body was the predominant site of protein synthesis in ...
Nevertheless, the commonality that exists in every consolidation phase is a short-lived destabilization of a memory object and a susceptibility for said object to react to amnesic agents—principally protein synthesis inhibitors. [5]
Internalization is dependent on protein synthesis, and p120 catenin proteins (p120ctn) are implicated in the turnover, degradation and ‘clustering’ of cadherins into the adhesive junctions at the synapse. [17] P120 ctn proteins are thought to either inhibit endocytosis of neural cadherins, or act at the cell surface to control cadherin ...
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For instance, it is possible that the behavioral interactions ascribed to synaptic tagging and capture are caused by protein synthesis-dependent increases in neuromodulators such as dopamine rather than by synaptic tagging mechanisms. Examining the behavioral effects under direct manipulation can help rule out these other possible causes.