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Nicotine has been used as an insecticide since at least 1690, in the form of tobacco extracts or as pure nicotine sulphate [19] [51] [52] (although other components of tobacco also seem to have pesticide effects). [53] It acts on the nicotinic acetylcholine receptor, and gave the receptor its name. Nicotine is in IRAC group 4B.
Natural American Spirit products in the year 2000 were advertised as "100% Additive-Free Tobacco". [citation needed]California Attorney General Jerry Brown announced on March 1, 2010, that his office had secured an agreement with the Santa Fe Natural Tobacco Company to clearly disclose that its organic tobacco is "no safer or healthier" than other tobacco products.
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Y1 has a higher nicotine content than conventional flue-cured tobacco (6.5% versus 3.2—3.5%), [16] but a comparable amount of tar, and does not affect taste or aroma. [17] British American Tobacco (BAT) began to discuss the trialling of Y1 tobacco in 1991, [ 18 ] despite it not being approved for use in the United States. [ 13 ]
Zyn pouches are sold in round cans containing 15 or 20 pouches depending on the market. Pouches are available in different levels of nicotine strength (such as 3 or 6 milligrams per pouch in the US) and different flavored and unflavored varieties. [17] The pouches contain nicotine extracted from tobacco leaves, and food grade ingredients. [18]
A study investigated smokers' perception on cigarette products thought of as "less harmful" than regular cigarettes. It found that 3.3% of respondents could name a brand of herbal cigarettes, which was higher than the 2.4% who could name a brand of nicotine replacement therapy. [7]
A 2015 meta-analysis on clinical trials found that e-cigarettes containing nicotine are more effective than nicotine-free ones for quitting smoking. [150] They compared their finding that nicotine-containing e-cigarettes helped 20% of people quit with the results from other studies that found nicotine replacement products helps 10% of people ...
In the 1970s, Brown & Williamson cross-bred a strain of tobacco to produce Y1, a strain containing an unusually high nicotine content, nearly doubling from 3.2 to 3.5%, to 6.5%. In the 1990s, this prompted the Food and Drug Administration to allege that tobacco companies were intentionally manipulating the nicotine content of cigarettes. [24]
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