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The nuclear lamina consists of two components, lamins and nuclear lamin-associated membrane proteins. The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B 1, B 2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle.
Interaction between lamin A and the nuclear envelope protein emerin appears to be crucial in muscle cells, with certain mutations in lamin mimicking mutations in emerin and causing Emery–Dreifuss muscular dystrophy. Different mutations lead to dominant-negative and recessive alleles.
A study analyzed the DNA of feral dogs living near Chernobyl, compared the animals to others living 10 miles away, and found remarkable differences. ... As the world’s greatest nuclear disaster ...
Dr. Norman Kleiman, a co-author of the study, said, “Most people think of the Chernobyl nuclear accident as a radiological disaster in an abandoned corner of Ukraine, but the potential adverse ...
Meanwhile, this study has found that feral dogs living in the area showed distinct genetic differences from dogs living only 10 miles away. It’s still early days, however, and it’s not ...
The very first modification involving farnesylation of prelamin A is crucial to the development of mature lamin A. Isoform lamin C does not undergo posttranslational modifications. [ 9 ] [ 13 ] Some studies have demonstrated that lamins A and C are not required for the formation of the nuclear lamina, yet disruptions in the LMNA gene can ...
After the 1986 nuclear disaster in Chernobyl, the regional domestic dog population suffered from environmental pollution originating from the radiation. This disaster made the environment highly mutagenic, leading to various evolutionary processes including, but not limited to, bottlenecks , directional selection , and higher rates of mutation ...
Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs).