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56335 Ensembl ENSG00000165819 ENSMUSG00000022160 UniProt Q86U44 Q8C3P7 RefSeq (mRNA) NM_019852 NM_019721 RefSeq (protein) NP_062826 NP_062695 Location (UCSC) Chr 14: 21.5 – 21.51 Mb Chr 14: 52.53 – 52.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. METTL3 is ...
In 1989, two scientific groups came up with the hypothesis that the thymus expresses genes which are in the periphery, strictly expressed by specific tissues (e.g.: Insulin produced by β cells of the pancreas) to subsequently present these so-called "tissue-restricted antigens" (TRAs) from almost all parts of the body to developing T cells in order to test which TCRs recognize self-tissues ...
Thymocytes are classified into a number of distinct maturational stages based on the expression of cell surface markers. The earliest thymocyte stage is the double negative stage (negative for both CD4 and CD8), which more recently has been better described as Lineage-negative, and which can be divided into four substages.
Major function of cTECs is to positively select those T cells that are capable to recognize and interact with MHC molecules on their surface [3]. Once T cell precursors enter the thymic cortex, they start their transformation from double negative stages (T cell without surface expression of CD4 and CD8 co-receptors) to a double positive stage (T cell with surface expression of both co ...
The thymic microenvironment is established by TEC network filled with thymocytes (blood cell precursors of T cells) in different developing stages. TECs and thymocytes are the most important components in the thymus, that are necessary for production of functionally competent T lymphocytes and self tolerance .
a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD6: adhesion molecule linking developing thymus-cells to thymus epithelial cells; co-stimulator to mature T cells ...
Thymocytes uptake The thymic cortical cells take up early thymocytes migrating from the bone marrow to the thymus and form the thymocyte-TNC complexes. The formation of finger-like projections has been found to facilitate this uptake; which also requires the participation of membrane and cytoskeleton proteins of TECs and thymocytes.
Thymocytes that interact too strongly with the self-antigen receive an apoptotic signal that leads to cell death. However, some of these cells are selected to become Treg cells. The remaining cells exit the thymus as mature naive T cells , also known as recent thymic emigrants. [ 13 ]
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