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Povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. [6] Chemical pleurodesis is a painful procedure, and so patients are often premedicated with a sedative and analgesics. A local anesthetic may be instilled into the pleural space, or an epidural catheter may be placed for ...
An intrapleural chest tube is also known as a Bülau drain or an intercostal catheter (ICC), and can either be a thin, flexible silicone tube (known as a "pigtail" drain), or a larger, semi-rigid, fenestrated plastic tube, which often involves a flutter valve or underwater seal.
Sterile talc powder (NDC 63256-200-05) is a sclerosing agent used in the procedure of pleurodesis. This can be helpful as a cancer treatment to prevent pleural effusions (an abnormal collection of fluid in the space between the lungs and the thoracic wall). It is inserted into the space via a chest tube, causing it to close up, so fluid cannot ...
Inflammation may be induced by either physical or chemical irritation. The former is commonly used in younger patients and involves surgical abrasion. The latter involves the instillation of chemical sclerosant, usually sterile talc, via a chest tube. Other sclerosing agents include tetracycline and bleomycin. [30]
The pleural cavity, or pleural space (or sometimes intrapleural space), is the potential space between the pleurae of the pleural sac that surrounds each lung.A small amount of serous pleural fluid is maintained in the pleural cavity to enable lubrication between the membranes, and also to create a pressure gradient.
VATS may also be used to achieve chemical pleurodesis; this involves insufflation of talc, which activates an inflammatory reaction that causes the lung to adhere to the chest wall. [ 12 ] [ 15 ] If a chest tube is already in place, various agents may be instilled through the tube to achieve chemical pleurodesis , such as talc, tetracycline ...
In rare cases, mesothelioma has also been associated with irradiation of the chest or abdomen, intrapleural thorium dioxide as a contrast medium, and inhalation of other fibrous silicates, such as erionite or talc. [12] [26] Some studies suggest that simian virus 40 may act as a cofactor in the development of mesothelioma. [26]
The mechanism underlying this link is not clearly understood. Ritalin tablets are not intended to be injected. They contain talc as a filler, and it has been suggested that talc exposure causes granulomatosis leading to alveolar destruction. However, other intravenous drugs also contain talc, and no emphysematous change is associated with those.