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Vitamin B 12 deficiency can be determined, but not always. [15] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [152] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
Symptoms “A B12 deficiency can cause physical and neurological symptoms, and research is also growing to support that it can also cause psychological issues as well,” says Shapiro.
A vitamin B12 deficiency can be caused by a gastrointestinal disorder or a lack of B12 in your diet. Signs of a B12 deficiency include weakness, fatigue, and tingling or numbness in the hands and ...
The Schilling test distinguished PA from other forms of B 12 deficiency, [50] specifically, from Imerslund–Gräsbeck syndrome, a B 12-deficiency caused by mutations in CUBN that codes for cubilin the cobalamin receptor. [1] Vitamin B12 deficiency is also prevalent in patients having Crohn's disease (CD) so it should be differentiated. [62]
But having lower vitamin B12 levels doesn’t automatically mean that someone’s symptoms are being caused by the deficiency. “B12 deficiency is also more common in people with Alzheimer’s ...
Deficiency can also result from rare genetic factors, such as mutations in the MTHFR gene that lead to compromised folate metabolism. [33] [34] Cerebral folate deficiency is a rare condition in which concentrations of folate are low in the brain despite being normal in the blood. [35] Vitamin B 12 deficiency: Anemia, neurological and digestive ...
Vitamin B12 deficiency symptoms. In addition to weakness and fatigue, a B12 deficiency may also prompt a slew of other symptoms, depending on the severity, including: pale skin.
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