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Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. [1] CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or ...
Overall, leukemia is the eleventh most common cancer in the UK (around 8,600 people were diagnosed with the disease in 2011), and it is the ninth most common cause of cancer death (around 4,800 people died in 2012). History Rudolf Virchow. Leukemia was first described by anatomist and surgeon Alfred-Armand-Louis-Marie Velpeau in 1827.
Leukemia Society (1955–1965) Leukemia Society of America (1966–1999) The Leukemia & Lymphoma Society (LLS), a 501 (c) (3) charitable organization founded in 1949, is a voluntary health organization dedicated to fighting blood cancer world-wide. LLS funds blood cancer research on cures for leukemia, lymphoma, Hodgkin's disease, and myeloma.
Lymphoma. Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell ). [7] The name typically refers to just the cancerous versions rather than all such tumours. [7] Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling ...
Tumors of the hematopoietic and lymphoid tissues ( American English) or tumours of the haematopoietic and lymphoid tissues ( British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. [1] [2] Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease ...
Monoclonal B-cell lymphocytosis. Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic condition in which individuals have increased blood levels of particular subtypes of monoclonal lymphocytes (i.e. an aberrant and potentially malignant group of lymphocytes produced by a single ancestral cell). This increase must persist for at least 3 ...
Acute lymphoblastic leukemia (ALL) is a condition where immature white blood cells accumulate in the bone marrow, subsequently crowding out normal white blood cells [7] and create build-up in the liver, spleen, and lymph nodes. [8] The two most common types of ALL are B-lymphocytes and T-lymphocytes, where the first protects the body against ...
Cancer is caused by genetic changes leading to uncontrolled cell growth and tumor formation. The basic cause of sporadic (non-familial) cancers is DNA damage and genomic instability. [1] [2] A minority of cancers are due to inherited genetic mutations. [3] Most cancers are related to environmental, lifestyle, or behavioral exposures. [4]
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