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Epidemiological (and other observational) studies typically highlight associations between exposures and outcomes, rather than causation. While some consider this a limitation of observational research, epidemiological models of causation (e.g. Bradford Hill criteria) [7] contend that an entire body of evidence is needed before determining if an association is truly causal. [8]
By creating a case definition, public health professionals are better equipped to study an outbreak and determine possible causes. As investigations proceed, a case definition may be expanded or narrowed, a characteristic of the dynamic nature of outbreak investigations. At any given time, the case definition is supposed to be the gold standard ...
Case series have a descriptive study design; unlike studies that employ an analytic design (e.g. cohort studies, case-control studies or randomized controlled trials), case series do not, in themselves, involve hypothesis testing to look for evidence of cause and effect (though case-only analyses are sometimes performed in genetic epidemiology ...
In medicine, a case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient. Case reports may contain a demographic profile of the patient, but usually describe an unusual or novel occurrence. Some case reports also contain a literature review of other reported cases.
Researchers have applied Hill’s criteria for causality in examining the evidence in several areas of epidemiology, including connections between exposures to molds and infant pulmonary hemorrhage, [14] ultraviolet B radiation, vitamin D and cancer, [15] [16] vitamin D and pregnancy and neonatal outcomes, [17] alcohol and cardiovascular ...
Porta's Dictionary of Epidemiology defines the case–control study as: "an observational epidemiological study of persons with the disease (or another outcome variable) of interest and a suitable control group of persons without the disease (comparison group, reference group). The potential relationship of a suspected risk factor or an ...
A case fatality ratio is a comparison between two different case fatality rates, expressed as a ratio. It is used to compare the severity of different diseases or to assess the impact of interventions. [6] Because the CFR is not an incidence rate by not measuring frequency, some authors note that a more appropriate term is case fatality ...
Clinical epidemiology aims to optimise the diagnostic, treatment and prevention processes for an individual patient, based on an assessment of the diagnostic and treatment process using epidemiological research data. [7] [8] A central tenet of clinical epidemiology is that every clinical decision must be based on rigorously evidence-based ...