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Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage.
Summarize the pathophysiology of essential hypertension and its pathological sequelae on organ systems throughout the body. Review the various treatment options for treating essential hypertension, both pharmacological as well as lifestyle modification strategies.
In general, hypertension is a blood pressure reading of 130/80 millimeters of mercury (mm Hg) or higher. The American College of Cardiology and the American Heart Association divide blood pressure into four general categories.
Patients with hypertension demonstrate abnormalities of vessel wall (endothelial dysfunction or damage), the blood constituents (abnormal levels of haemostatic factors, platelet activation, and fibrinolysis), and blood flow (rheology, viscosity, and flow reserve), suggesting that hypertension confers a prothrombotic or hypercoagulable state.
The pathogenesis of essential hypertension (primary hypertension, idiopathic hypertension) is multifactorial and highly complex, often involving reciprocal influences between different...
Pathophysiology |. Symptoms and Signs |. Diagnosis |. Treatment |. Prognosis |. Key Points |. More Information. Hypertension is sustained elevation of resting systolic blood pressure (≥ 130 mm Hg), diastolic blood pressure (≥ 80 mm Hg), or both. Hypertension with no known cause (primary; formerly, essential, hypertension) is most common.
Pathophysiology of Hypertension. The Mosaic Theory and Beyond. David G. Harrison , Thomas M. Coffman, Christopher S. Wilcox. ABSTRACT: Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage.
Pathophysiology. Hypertension is a chronic elevation of blood pressure that, in the long-term, causes end-organ damage and results in increased morbidity and mortality. Blood pressure is the product of cardiac output and systemic vascular resistance.
Compendium on the Pathophysiology and Treatment of Hypertension. Adherence in Hypertension. A Review of Prevalence, Risk Factors, Impact, and Management. Michel Burnier, Brent M. Egan. Abstract: The global epidemic of hypertension is largely uncontrolled and hypertension remains the leading cause of noncommunicable disease deaths worldwide.
The pathophysiology of hypertension is an area which attempts to explain mechanistically the causes of hypertension, which is a chronic disease characterized by elevation of blood pressure. Hypertension can be classified by cause as either essential (also known as primary or idiopathic) or secondary.