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They inhibit release of thyroid hormones by the thyroid gland.The most studied drug in this class is lithium, which inhibits thyroid hormone secretion by inhibiting iodotyrosine coupling, thyroidal iodide uptake, and alteration in structure of thyroglobulin, [10] a protein which acts as a substrate for the synthesis of thyroid hormones and storage of inactive forms of T3, T4 and iodine within ...
Furthermore, reviewing their medications and possible dietary supplements is important, as several medications can affect thyroid hormone levels. [ 14 ] Levothyroxine is also used to treat subclinical hypothyroidism , which is defined by an elevated TSH level and a normal-range free T 4 level without symptoms. [ 14 ]
Thiamazole is a cyclic thiourea derivative that works by decreasing the production of thyroid hormones. [2] Thiamazole was approved for medical use in the United States in 1950. [2] It is on the World Health Organization's List of Essential Medicines. [5] [6] It is available as a generic medication. [2] It is also available in Europe and Asia. [7]
[1] [2] Some thyromimetic drugs are selective for various of these receptors over others, enabling more targeted effects and reducing toxicity. Thyromimetics selective for TRβ—including eprotirome , [ 3 ] sobetirome , [ 4 ] resmetirom , [ 5 ] and the prodrug VK2809 —have been investigated for the treatment of non-alcoholic fatty liver ...
Propylthiouracil is in the antithyroid family of medications. [4] It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3). [3] Propylthiouracil came into medical use in the 1940s. [5] It is on the World Health Organization's List of Essential ...
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T 3 and T 4 . It is on the World Health Organization's List of Essential Medicines.
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