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The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
When TNF binds to its receptors, tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2), a pathway of signals is triggered within the target cell, resulting in an inflammatory response. sTNF can only activate TNFR1, whereas tmTNF can activate both TNFR1 and TNFR2, [6] as well as trigger inflammatory signaling ...
Protein (member #) Synonyms Gene Ligand(s) 1: Tumor necrosis factor receptor 1 (1A) CD120a TNFRSF1A: TNF (cachectin) Tumor necrosis factor receptor 2 (1B) CD120b TNFRSF1B: 3 Lymphotoxin beta receptor (3) CD18 LTBR: Lymphotoxin beta (TNF-C) 4 OX40 (4) CD134 TNFRSF4: OX40L: 5 CD40 (5) Bp50 CD40: CD154: 6 Fas receptor (6) Apo-1, CD95 FAS: FasL ...
To grow one pound of new muscle, most people need to consume around 1 gram of protein per pound of body weight per day, paired with consistent strength training, according to a 2017 systematic ...
619441 Ensembl ENSG00000248871 ENSMUSG00000018752 UniProt O43508 n/a RefSeq (mRNA) NM_172089 NM_001034097 NM_001034098 NM_001159503 RefSeq (protein) NP_003800 n/a Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.57 – 69.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human ...
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/ TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene. [ 5 ] 4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137).
8740 50930 Ensembl ENSG00000125735 ENSMUSG00000005824 UniProt O43557 Q9QYH9 RefSeq (mRNA) NM_003807 NM_172014 NM_001376887 NM_019418 RefSeq (protein) NP_003798 NP_742011 NP_001363816 NP_062291 Location (UCSC) Chr 19: 6.66 – 6.67 Mb Chr 17: 57.5 – 57.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a ...