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2. Prevention of migraine attacks - Wikipedia

   en.wikipedia.org/wiki/Prevention_of_migraine_attacks

   The most commonly prescribed drugs for migraine prevention are beta-blockers, antidepressants, and anticonvulsants. The drugs are started at a low dose, which is gradually increased until therapeutic effects develop, the ceiling dose for the chosen drug is reached, or side effects become intolerable.

3. Antimigraine drug - Wikipedia

   en.wikipedia.org/wiki/Antimigraine_drug

   Beta blockers have been deemed effective options for the prevention of migraines. In particular, metoprolol, timolol and propranolol have the most strength of efficacy. [9] The timeframe to effectiveness in generally within 3 months. [9] Patients with cardiovascular risk factors should avoid the use of beta blockers for migraine prevention. [9]

4. Pizotifen - Wikipedia

   en.wikipedia.org/wiki/Pizotifen

   Pizotifen is able to dose-dependently and fully antagonize the discriminative stimulus effects of the serotonin–norepinephrine–dopamine releasing agent and serotonin 5-HT 2 receptor agonist MDMA in rodent drug discrimination tests. [10] Conversely, the related drug cyproheptadine was only partially effective and clozapine was ineffective. [10]

5. Beta blocker - Wikipedia

   en.wikipedia.org/wiki/Beta_blocker

   Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects. [76] Central nervous system-related side effects and risks of beta blockers may include fatigue , depression , sleep disorders (namely insomnia ) and nightmares , visual ...

6. Timolol - Wikipedia

   en.wikipedia.org/wiki/Timolol

   Other side effects include masking the symptoms of low blood sugar in those with diabetes. [3] Use is not recommended in those with asthma, uncompensated heart failure, or chronic obstructive pulmonary disease (COPD). [3] It is unclear if use during pregnancy is safe for the fetus. [6] Timolol is a non-selective beta blocker. [3]

7. Management of migraine - Wikipedia

   en.wikipedia.org/wiki/Management_of_migraine

   Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...