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The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, ...
Cortico-basal ganglia-thalamo-cortical loop [ edit ] The dopaminergic pathways that project from the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) into the striatum (i.e., the nigrostriatal and mesolimbic pathways, respectively) form one component of a sequence of pathways known as the cortico-basal ganglia-thalamo ...
The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain. The loop involves connections between the cortex , the basal ganglia , the thalamus , and back to the cortex.
An addictive drug is defined as a substance that affects the mesolimbic system directly or indirectly by increasing extracellular levels of dopamine. [ 24 ] Common addictive substances such as cocaine , alcohol , and nicotine have been shown to increase extracellular levels of dopamine within the mesolimbic pathway, preferentially within the ...
The Papez circuit / p eɪ p z /, [1] [2] [unreliable source?] [3] or medial limbic circuit, is a neural circuit for the control of emotional expression. In 1937, James Papez proposed that the circuit connecting the hypothalamus to the limbic lobe was the basis for emotional experiences.
This circuit connects the frontal monitoring systems to the limbic system. Dysfunction of this circuit often results in personality change including behavioral disinhibition, emotional lability, aggressive outbursts, poor judgment, and lack of interpersonal sensitivity. [2] [11]
The reward system (the mesocorticolimbic circuit) is a group of neural structures responsible for incentive salience (i.e., "wanting"; desire or craving for a reward and motivation), associative learning (primarily positive reinforcement and classical conditioning), and positively-valenced emotions, particularly ones involving pleasure as a core component (e.g., joy, euphoria and ecstasy).
1392 12918 Ensembl ENSG00000147571 ENSMUSG00000049796 UniProt P06850 Q8CIT0 RefSeq (mRNA) NM_000756 NM_205769 RefSeq (protein) NP_000747 NP_991338 Location (UCSC) Chr 8: 66.18 – 66.18 Mb Chr 3: 19.75 – 19.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin ; corticotropin ...