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In vitro fertilization (IVF) is a process of fertilization in which an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating a woman's ovulatory process, then removing an ovum or ova (egg or eggs) from her ovaries and enabling a man's sperm to fertilise them in a culture medium in a laboratory.
Insemination is the introduction of sperm (in semen) into a female or hermaphrodite's reproductive system in order to fertilize the ovum through sexual reproduction. [1] [2] The sperm enters into the uterus of a mammal or the oviduct of an oviparous (egg-laying) animal.
Although the pregnancy was successful, it was later determined that the fertilisation occurred in vivo (in the body). [3] Miriam Menkin was the first to extract an intact fertilised egg. [4] In 1948, John Rock and Miriam Menkin retrieved over 800 oocytes, of which 138 were exposed to spermatozoa in vitro.
Human fertilization is the union of an egg and sperm, occurring primarily in the ampulla of the fallopian tube. [1] The result of this union leads to the production of a fertilized egg called a zygote, initiating embryonic development. Scientists discovered the dynamics of human fertilization in the 19th century. [2]
The first recorded case of artificial insemination was John Hunter in 1790, who helped impregnate a linen draper's wife. [1] [2] The first reported case of artificial insemination by donor occurred in 1884: William H. Pancoast, a professor in Philadelphia, took sperm from his "best looking" student to inseminate an anesthetized woman without her knowledge.
In vitro fertilization: once the egg is obtained it is fertilized with the donor sperm in a laboratory. [7] This can be done by ICSI technique or regular In vitro fertilization. Once the egg is fertilized, embryos are obtained that are kept in the lab for 3 to 5 days, when they develop to blastocysts. [ 8 ]
Edwards died at home near Cambridge, England [36] on 10 April 2013 after a long lung illness. [37] A spokesperson for the University of Cambridge said "He will be greatly missed by family, friends and colleagues." [38] The Guardian reported that, as of Edwards' death, more than four million births had resulted from IVF. [38]
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