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Treatment typically takes place in hospital such as in a burn unit or intensive care unit. [3] [7] Efforts include stopping the cause, pain medication, and antihistamines. [3] [4] Antibiotics, intravenous immunoglobulins, and corticosteroids may also be used. [3] [4] Treatments do not typically change the course of the underlying disease. [3]
This spectrum of disorders is complicated by inflammation in and damage to internal organs such as the liver and, less commonly, kidney and heart. More importantly, they are also complicated by sepsis due to the loss of skin and mucous membrane epithelial barriers. In one study, SJS, TEN, and SJS/TEN mortality rates were 4.8%, 19.4%, and 14.8% ...
The culprit can be both a prescription drug or an over-the-counter medication. Examples of common drugs causing drug eruptions are antibiotics and other antimicrobial drugs, sulfa drugs , nonsteroidal anti-inflammatory drugs (NSAIDs), biopharmaceuticals , chemotherapy agents, anticonvulsants and psychotropic drugs .
NAPQI therefore remains in its toxic form in the liver and reacts with cellular membrane molecules, resulting in widespread hepatocyte damage and death, leading to acute liver necrosis. [ 35 ] [ 40 ] In animal studies, the liver's stores of glutathione must be depleted to less than 70% of normal levels before liver toxicity occurs.
Over time, this can lead to another type of liver disease called NAFLD . While the cause isn’t 100% clear, it is often linked to overweight, obesity, type 2 diabetes , metabolic syndrome, high ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
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An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, and methadone. [3] [5] This preventable pathology can be fatal if it leads to respiratory depression, a lethal condition that can cause hypoxia from slow and shallow breathing. [3]