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Activation of a wide range of serotonin receptors by serotonin itself or by certain prokinetic drugs results in enhanced gastrointestinal motility. [3] Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M 1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which ...
Drugs that increase the transit time of gabapentin in the small intestine can increase its oral bioavailability; when gabapentin was co-administered with oral morphine (which slows intestinal peristalsis), [27] the oral bioavailability of a 600 mg dose of gabapentin increased by 50%. [24]
[5] [6] This compound is a stimulant laxative and increases peristalsis in the gut. [5] [7] Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies. [5] [8]
Peristalsis (/ ˌ p ɛr ɪ ˈ s t æ l s ɪ s / PERR-ih-STAL-siss, US also /-ˈ s t ɔː l-/- STAWL-) [1] is a type of intestinal motility, characterized by radially symmetrical contraction and relaxation of muscles that propagate in a wave down a tube, in an anterograde direction. Peristalsis is progression of coordinated contraction of ...
The increase in prolactin levels observed with the two drugs was much greater in women than in men. [74] [75] This appears to be due to the higher estrogen levels in women, as estrogen stimulates prolactin secretion from the pituitary gland. [76]
Also, BSS inhibits cyclooxygenase enzyme and leads to a decrease in the production of prostaglandins, which are compounds that increase intestinal inflammation and motility. [1] Lastly, this antidiarrheal agent enhances fluid reabsorption, which helps improve diarrhea symptoms and stool consistency. [1]
The topical administration of medications into the rectum, such as corticosteroids and mesalazine used in the treatment of inflammatory bowel disease. Administration by enema avoids having the medication pass through the entire gastrointestinal tract , therefore simplifying the delivery of the medication to the affected area and limiting the ...
Motilin is a 22-amino acid polypeptide hormone in the motilin family that, in humans, is encoded by the MLN gene. [2]Motilin is secreted by endocrine Mo cells [3] [4] (also referred to as M cells, which are not the same as the M cells, or microfold cells, found in Peyer's patches) that are numerous in crypts of the small intestine, especially in the duodenum and jejunum. [5]