Search results
Results from the WOW.Com Content Network
Hyperpolarization. This hyperpolarization phase also cannot be explained by an artifact such as fluorescence dequenching of the mitochondrial probe (sometimes observed when it is used in high concentration) since these events were still observable at as low as 12 nM of TMRM (Fig. 9), which is 1–2 orders less than that needed to observe fluorescence dequenching of mitochondrially-sequestered ...
Hyperpolarized 13C MRS imaging (MRSI) is an emerging method, with the ability to transiently enhance the MR signal of 13C-enriched molecules by > 10.000 times.5One of the most widely studied 13C-probes in hyperpolarized MRSI is 13C enriched pyruvate1. Pyruvate is the end-product of intracellular glycolysis.
The hyperpolarization activated current I h has long been recognized as having an important role in rhythmic biological functions such as thalamo-cortical oscillations, the sleep/wake cycle [43], and neuronal synchronization [3]. We have investigated the current because it plays a fundamental role in determining characteristics of a neuron's ...
The H current (I h) is a hyperpolarization-activated, time- and voltage-dependent, nonselective cation current that when activated causes depolarization of the membrane, tending to reduce afterhyperpolarization duration, increase firing frequency, and decrease adaptation. 233 An H current is prominent in most or all large DRG neurons but in ...
The hyperpolarization of the rod outer segment propagates passively (i.e., without firing an action potential) through the perikaryon to the rod spherule. In the absence of light, the photoreceptor terminals constantly release the transmitter glutamate at these synapses.
Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude.
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a crucial role in regulating neuronal excitability. Despite growing evidence supporting the therapeutic potential of HCN1 inhibition in treating neurological disorders, the structural basis of channel inhibition by inhibitor has remained elusive.
Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are involved in spontaneous activity in many electrically active cell types such as cardiomyocytes and neurons. In this study, the role of HCN channels in proliferation and migration of Nestin and Sox2 expressing embryonic neural progenitor cells (NPC) originating from ...
Hyperpolarized [1– 13 C]pyruvate is the leading metabolite used in the emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) is a straight forward hyperpolarization method that has recently been shown to hyperpolarize [1– 13 C]pyruvate at low (microtesla and below) magnetic fields. Here, we ...
Although surprising, hyperpolarization of the mitochondria has been described before in cells with reduced activity of complex I [1], [10]. Interestingly, a higher ΔΨm has also been observed in isolated mitochondria from the P301L tau mice model [7] and in iPSC-derived motor neurons of the C9ORF72 model of ALS/FTD [29].